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目的首次报道3 例大观霉素治疗淋病失败病例,对其原因进行了研究分析。方法以氧化酶试验和糖发酵试验鉴定3 株淋球菌,用琼脂稀释法进行体外药物敏感性试验。结果 3 株菌均氧化酶阳性,糖发酵试验仅分解葡萄糖, 鉴定为淋球菌。药物敏感性试验3株淋球菌均对头孢曲松敏感,对环丙沙星耐药;2株淋球菌为耐大观霉素淋球菌,其中1株亦为产青霉素酶淋球菌(PPNG);第3株淋球菌为大观霉素敏感菌株,但为 PPNG 及耐四环素淋球菌(TRNG)。病史提示第3 例患者是因为药物注射不当或吸收剂量不足而至治疗失败。结论大观霉素治疗淋病失败的原因有耐药问题,还有注射不当。
Objective To report the first case of 3 cases of spectinomycin treatment of gonorrhea failure cases, the reasons for the study analyzed. Methods Three strains of Neisseria gonorrhoeae were identified by oxidase test and sugar fermentation test. In vitro drug susceptibility test was performed by agar dilution method. Results Three strains were positive for each oxidase. The glucose fermentation test only decomposed glucose and was identified as Neisseria gonorrhoeae. Three strains of Neisseria gonorrhoeae were sensitive to ceftriaxone and resistant to ciprofloxacin. Two strains of Neisseria gonorrhoeae were resistant to spectinomycin gonococci, of which one strain was also penicillinase-producing Neisseria gonorrhoeae (PPNG) Three strains of N. gonorrhoeae were spectinomycin sensitive strains, but PPNG and tetracycline resistant neisseria gonorrhoeae (TRNG). The medical history indicated that the third patient failed the treatment because of improper injection or inadequate dose. Conclusion The reasons for the failure of spectinomycin treatment of gonorrhea are drug resistance problems, as well as improper injection.