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目的:探讨高原低氧状态对诱导实验鼠细胞应激性的作用和影响。方法:设定A,B,C 3组,分别再将其分为实验组(A1,B1,C1)和对照组(A2,B2,C2),每小组18只,共108只实验鼠,雌雄各半,A组和C组用CR小鼠,B组用Wistar大鼠,A1组分析快速进入海拔3 820 m的缺氧诱导因子-1α表达特点;B1组置于400~420 kPa低压氧舱内压下,观察不同低氧暴露时间对大鼠心肌线粒体的影响;C组分析对比在不同海拔高度、不同氧浓度、不同天数的血浆血管内皮生长因子表达水平。对照组在海拔800 m进行实验。结果:A1组内皮素-1α的浓度逐渐上升,小鼠心肌细胞缺氧诱导因子-1α实验A1组阳性显著高于A2组;B组随进入低氧环境的天数延长,大鼠心肌线粒体的数量发生不同改变;C1组血管内皮生长因子浓度随天数增加而增加,与C2组比较差异有统计学意义。结论:低氧低压环境条件可促进实验鼠心肌细胞缺氧诱导因子-1α表达,实验鼠有低氧适应(习服)过程,血管内皮生长因子调控与氧含量相关,随氧含量下降而表达上升。
Objective: To investigate the role and influence of plateau hypoxia on stress induced in experimental rat cells. Methods: A, B, C groups were divided into experimental group (A1, B1, C1) and control group (A2, B2 and C2) In each group, CR mice were used in group A and group C, Wistar rats were used in group B, and the expression of hypoxia-inducible factor-1α at 3 820 m altitude was rapidly analyzed in group A1; group B1 was placed in hypobaric chamber 400 ~ 420 kPa The effects of different hypoxic exposure time on the mitochondria of myocardium were observed under internal pressure. The expression of vascular endothelial growth factor (VEGF) at different altitude, different oxygen concentration and different days in group C were compared. Control group at 800 m altitude for experiments. Results: The concentration of endothelin-1α in group A1 gradually increased. The positive rate of hypoxia-inducible factor-1α in group A1 was significantly higher than that in group A2. The number of mitochondria in group B was increased as the number of days went into hypoxia, With different changes. The concentration of vascular endothelial growth factor in group C1 increased with the increase of days, which was statistically significant compared with C2 group. CONCLUSION: Hypoxic hypobaric hypoxic environment can promote hypoxia-inducible factor-1α expression in experimental rat cardiomyocytes. Hypoxia acclimatization is observed in experimental rats. The regulation of vascular endothelial growth factor is related to oxygen content, and increases with the decrease of oxygen content .