The Late Cretaceous tectonic upheaval was an important event during the evolution of the Qaidam Basin, resulting in the omission of the Upper Cretaceous in the whole basin and unconformities between the Paleogene sequence and pre-K2 strata. Inte-grating geological and geophysical data, two different groups of Late Cretaceous faults were recognized in the study area, one group consisting of E-W extending strike-slip faults (e.g., the Maxian and Yema-Jinan faults in the Mahai area, which caused an E-W omission zone of Mesozoic), while the other one has NW-SE thrust faults, resulting in NW-SE fold-and-thrust belts. Considering the different strikes and scale of these two groups, a simple-shear model has been employed to explain this structural phenomenon. The NW-SE thrust faults were thought to be subsidiary to the E-W strike-slip faults. Putting this into the framework of the Cretaceous paleogeographic environment of central Asia, it is inferred that this tectonic event of the Qaidam Basin is a response to the continuous northward drifting of the India plate. The Late Cretaceous tectonic upheaval was an important event during the evolution of the Qaidam Basin, resulting in the omission of the Upper Cretaceous in the whole basin and unconformities between the Paleogene sequence and pre-K2 strata. Inte-grating geological and geophysical data, two different groups of Late Cretaceous faults were recognized in the study area, one group consisting of EW extending strike-slip faults (eg, the Maxian and Yema-Jinan faults in the Mahai area, which caused an EW omission zone of Mesozoic), while the other one has NW-SE thrust faults, resulting in NW-SE fold-and-thrust belts. Considering the different strikes and scale of these two groups, a simple-shear model has been employed to explain this structural phenomenon. thrust faults were thought to be subsidiary to the EW strike-slip faults. Putting this into the framework of the Cretaceous paleogeographic environment of central Asia, it is inferred that this tectonic event of the Qaidam Bas in is a response to the continuous northward drifting of the India plate.