药理学中最棘手的问题是解释药物的慢性毒性,近来新的更复杂的问题是对药物畸胎形成性的评价。以前仅评价药物对生殖的影响,从未系统研究畸胎形成作用。达利陀迈(Thalidomide)事件使药理界大为震惊,开始重视胚胎学研究。研究历史已久。1950年胚胎学家借各种类型的物质引起先天性畸形,如物理因素、病毒、维生素缺乏或过多、抗代谢剂或固醇类。这些成果在1962年医生开始研究药物引起畸胎 The thorniest issue in pharmacology is to explain the chronic toxicity of drugs. Recently a new and more complex problem is the evaluation of teratogenicity of the drug. Previously only the impact of drugs on reproductive evaluation, teratogenic effect has never been systematically studied. The Thalidomide incident alarmed the pharmacology community and began to focus on embryology. The research has a long history. In 1950, embryologists caused congenital malformations by various types of substances, such as physical factors, viruses, vitamin deficiency or excess, antimetabolites or sterols. These results in 1962, doctors began to study the drug caused teratogenic