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目的研究COX-2抑制剂NS398对放射抗拒食管癌细胞裸鼠移植瘤的放射增敏作用。方法采用食管癌细胞悬液裸鼠皮下接种法建立裸鼠移植瘤模型,比较食管Eca109细胞和放射抗拒Eca109R50Gy细胞(接受总剂量50Gy照射)的致瘤能力。选取接种Eca109R50Gy细胞荷瘤裸鼠,随机分为NS398组、放射组、NS398+放射组和对照组。在干预的14d中记录移植瘤体积、重量,计算各组肿瘤抑制率和NS398的放射增敏比值(E/O)。结果 Eca109R50Gy细胞比Eca109细胞裸鼠体内致瘤能力高出40倍。NS398+放射治疗能显著抑制裸鼠移植瘤的生长,体积缩小和瘤重减轻最为明显(P<0.05)。1.5mg/kg NS398的放射增敏比值E/O=1.61(>1.4)。结论 NS398对人食管Eca109R50Gy细胞裸鼠移植瘤具有放射增敏作用,其中更深入的信号传导机制值得进一步研究。
Objective To study the radiosensitization effect of COX-2 inhibitor NS398 on xenografts in esophageal cancer cells. Methods The xenograft model of nude mice was established by subcutaneous inoculation of esophageal cancer cell suspension in nude mice. The tumorigenic ability of esophageal Eca109 cells and Eca109R50Gy cells (total dose 50 Gy irradiation) were compared. Eca109R50Gy tumor-bearing nude mice were randomly divided into NS398 group, radiation group, NS398 + radiation group and control group. The volume and weight of the xenografts were recorded 14 days after the intervention. The tumor inhibition rates of each group and the radiosensitization ratio (E / O) of NS398 were calculated. Results Eca109R50Gy cells had 40 times more tumorigenic capacity than Eca109 cells in nude mice. NS398 + radiation treatment can significantly inhibit the growth of nude mice xenografts, the most obvious reduction in volume and weight (P <0.05). Radiosensitization ratio of 1.5mg / kg NS398 E / O = 1.61 (> 1.4). Conclusion NS398 has a radiosensitizing effect on human esophageal Eca109R50Gy xenografts in nude mice, and more in-depth signal transduction mechanisms deserve further study.