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1目的 检测非霍奇金病的微小残留病。 2方法 应用 PCR扩增琼脂糖凝胶电泳检测法 ,测定 5 0例非霍奇金病 bcl- 2基因表达与 t(14;18)染色体易位的关系。 3结果 在这个易位中 ,位于 18q2 1 上 bcl- 2原癌基因与 14q32 上的 Ig H基因融合 ,使 bcl- 2基因表达失常。本组 5 0例淋巴瘤病人中 ,11例 (2 2 % )表达 t(14;18)易位 ,5例经过治疗已获得缓解的病人中 ,1例检测到 t(14;18)易位 ,随访 90 d后临床复发。 4结论 t(14;18)易位可作为人类细胞转化或肿瘤进展的重要分子标志之一 ,对于检测微小残留病有一定临床应用价值。
AIM To detect minimal residual disease in non-Hodgkin’s disease. 2 Methods PCR amplification agarose gel electrophoresis assay was used to determine the relationship between bcl-2 gene expression and t (14; 18) chromosomal translocation in 50 cases of non-Hodgkin’s disease. 3 Results In this translocation, the bcl-2 oncogene at 18q21 fused to the Ig H gene on 14q32, rendering the bcl-2 gene dysregulated. Of the 50 patients with lymphoma, 11 (22%) expressed t (14; 18) translocations and one of 5 patients who had been treated had a response to t (14; 18) translocation , Followed up for 90 days after clinical recurrence. 4 Conclusion t (14; 18) translocation can be used as one of the important molecular markers of human cell transformation or tumor progression, and has certain clinical value for the detection of minimal residual disease.