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目的 探讨血清转化生长因子β_1(TGF-β_1)水平与肝纤维化的关系及在肝纤维化中的诊断价值。方法对139例肝病患者血清采用ELISA法检测TGF-β_1水平,并同时采用放射免疫法检测血清HA、LN、Ⅳ-C等肝纤维化血清学指标。结果 随着病情加重、肝纤维化程度加深,血清TGF-β_1逐渐升高,以肝硬变组最明显;血清TGF-β_1水平与血清HA、LN、Ⅳ-C均呈明显的正相关,且与Ⅳ_C相关更密切。结论 血清TGF-β_1与肝纤维化有密切联系,其血清水平可反映肝纤维化的程度,可作为诊断肝纤维化的一项可靠的新的血清学指标。
Objective To investigate the relationship between the serum level of transforming growth factor β_1 (TGF-β_1) and hepatic fibrosis and its diagnostic value in hepatic fibrosis. Methods Serum samples of 139 patients with liver disease were detected by ELISA. The serum levels of HA, LN and Ⅳ-C were detected by radioimmunoassay. Results As the disease progressed, the degree of hepatic fibrosis deepened and the serum TGF-β 1 level increased gradually, which was the most obvious in cirrhosis group. The level of serum TGF-β 1 was positively correlated with serum HA, LN and Ⅳ-C And Ⅳ_C more closely related. Conclusions Serum TGF-β 1 is closely related to liver fibrosis. The serum level of TGF-β 1 can reflect the degree of liver fibrosis, which can be used as a reliable new serological index for diagnosing hepatic fibrosis.