阳离子表面活性剂型金属胶束(metallomicelles)是近期出现的一种新型功能胶束,由阳离子表面活性剂功能络合物自身或在共表面活性剂存在下形成,它不仅水溶性好,且具有双层正电荷结构,是模拟水解金属酶配位、疏水、静电作用方式的优良体系。 羟基及碱性基团是天然水解酶中重要的催化功能基,在合成分子中有效构建这些功能基使之具有类似天然酶的催化活性,是水解模拟酶设计的最主要问题。目前非金属模拟酶中难以使羟基解离成为有效的亲核试剂,但在一些设计巧妙的水解金属模拟酶中,金属离子的 Cationic surfactant-type metal micelles (metallomicelles) is a recent emergence of a new type of functional micelles, formed by the cationic surfactant functional complex itself or in the presence of a co-surfactant, it is not only water-soluble, and has a double Layer of positive charge structure is to simulate the hydrolysis of metal enzyme coordination, hydrophobic, electrostatic effect of the fine system. Hydroxyl and basic groups are important catalytic functional groups in natural hydrolase. The effective construction of these functional groups in synthetic molecules to make them have catalytic activity similar to that of natural enzymes is the most important issue in the design of hydrolytic mimic enzymes. At present, it is difficult to dissociate hydroxyl groups into effective nucleophiles in non-metallic mimic enzymes. However, in some well-designed hydrolyzed mimic enzymes, metal ions