目的 :探讨鼻内镜术中光和热对鼻黏膜的损伤。方法 :应用透射电镜技术 ,观察正常和光照不同时间后的兔鼻中隔黏膜及其改变。结果 :发现光照后纤毛分布不均 ,有粘连及脱落 ;随照射时间的延长 ,出现上皮细胞间距增大 ,纤毛分布稀疏、粗细不等 ,胞内线粒体肿胀、嵴消失 ,基质空泡化 ,上皮细胞核曲边 ,染色质呈块状分布、边集 ,细胞核接近细胞表面 ,且可见杯状细胞脱落。结论 :鼻内镜术中光和热对鼻黏膜及黏液纤毛有损伤作用 ,鼻内镜手术应尽量缩短手术时间 ,尤其是连续照射时间 Objective: To investigate the nasal endoscopic surgery light and heat damage to the nasal mucosa. Methods: Transmission electron microscopy was used to observe the nasal septum mucosa and its changes after normal and light exposure. Results: The distribution of cilia was found to be uneven, with adhesions and detachment after light irradiation. With the extension of irradiation time, the intercellular distance of epithelial cells increased, the cilia distributed sparsely, the thickness varied, the intracellular mitochondria became swollen, the cristae disappeared, the matrix became vacuolized, Curvilinear nucleus, chromatin was massive distribution, edge set, the nucleus close to the cell surface, and visible goblet cells shedding. Conclusion: In endoscopic surgery, light and heat damage the nasal mucosa and mucociliary. Nasal endoscopic surgery should shorten the operation time, especially the continuous irradiation time