恶性疾病高钙血症的病理生理机制虽不相同,而治疗上都近似。患者经成功的手术、化疗或放疗后,血钙可降低,但常难以治愈。因此,加速病人尿钙排泄是有益的。静滴盐水可使多数病人的血钙降低,乃因血容量扩张血液稀释,更重要的是钠水负荷导致肾小球滤过和尿钙排泄均增加。速尿及其它袢利尿剂可增加钠和钙的排泄,因此速尿已用于治疗高钙血症。但血容量不足可影响袢利尿剂的作用,除非病人体液超负荷,否则速尿不可常规用于高钙血症。内科治疗主要是用药物抑制破骨细胞骨的吸收,包括降钙素、糖皮质激素、光辉霉素、磷酸盐和二磷酸酯。目前在美国首选的是二磷酸酯,常用羟乙二磷酸二钠加入生理盐水缓慢静滴,每日一次共5日,约80%病人血钙 Although the pathophysiology of malignant disease hypercalcaemia is not the same, but the treatment is similar. Patients after successful surgery, chemotherapy or radiotherapy, serum calcium can be reduced, but often difficult to cure. Therefore, it is beneficial to speed up urinary calcium excretion in patients. Intravenous infusion of saline can reduce the majority of patients with calcium, but due to blood volume expansion hemodilution, more importantly, sodium water load led to increased glomerular filtration and urinary calcium excretion. Furosemide and other 袢 diuretics can increase the excretion of sodium and calcium, furosemide has been used to treat hypercalcemia. However, insufficient blood volume can affect the role of diuretics, diuretics can not be routinely used for hypercalcaemia unless the patient is overloaded with body fluids. Medical treatment is mainly the use of drugs to inhibit osteoclast bone absorption, including calcitonin, glucocorticoids, mithramycin, phosphate and diphosphate. At present in the United States is the preferred diphosphate, commonly used hypophosphite disodium slow intravenous infusion of saline, a total of 5 days a day, about 80% of patients with calcium