论文部分内容阅读
目的:探讨环氧化酶-2(COX-2)基因3’端非翻译区(3’UTR)区域8473T>C位点单核苷酸多态性改变与口腔鳞状细胞癌(OSCC)发生的相关关系。方法:采用TaqMan-MGB基因分型方法,分别检测168例OSCC患者和1032例健康对照的COX-2基因3’UTR区域8473T>C位点多态性分布,运用x2检验和多因素Logistic回归等分析其与OS-CC发生的相关性。结果:与健康对照组相比,OSCC患者中吸烟和饮酒者的比例较高,具有统计学差异,同时COX-2基因3’UTR区域8473T>C位点的TT和CC的频率较高(70.24%vs 66.96%,6.98%vs 2.42%),而TC的频率较低(26.79%vs 30.62%),但是其基因型分布差异不具有统计学意义。结论:①烟酒摄入可能会增加OSCC发生的风险;②COX-2基因3’UTR区域8473T>C位点多态性改变可能与中国汉族人群中OSCC的发生不具有相关性。
OBJECTIVE: To investigate the association of single nucleotide polymorphism (SNP) 8473T> C in 3’UTR region of cyclooxygenase-2 (COX-2) gene with oral squamous cell carcinoma (OSCC) The relationship between. Methods: The genotype distribution of 8473T> C in COX-2 gene of 168 patients with OSCC and 1032 healthy controls was detected by TaqMan-MGB genotyping method. Chi-square test and multivariate Logistic regression Analyze its association with OS-CC. Results: Compared with healthy control group, the proportion of smoking and drinking drinkers in OSCC patients was statistically significant, and the frequency of TT and CC in 8473T> C site of COX-2 gene was higher in the 3’UTR region (70.24 % vs 66.96%, 6.98% vs 2.42%), while the frequency of TC was lower (26.79% vs 30.62%). However, the genotype distributions were not statistically significant. Conclusion: (1) Tobacco and alcohol intake may increase the risk of OSCC. (2) The polymorphism of 8473T> C in 3’UTR region of COX-2 gene may not be related to the occurrence of OSCC in Chinese Han population.