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目的探讨在中国人群中开展多种疫苗不同部位同时接种的安全性,为其进一步推广提供科学依据。方法选择2004年6月～2006年8月到广东国际旅行卫生保健中心接受预防接种的赴美移民申请者为调查对象,采用自填式调查表和电话报告相结合的方法收集受种者接种后不良反应情况,并与国外研究结果进行比较。结果772名受种者,接种后7d内不良反应报告率为49.6%,其中局部反应报告率为39.8%,全身反应为20.1%,与国外同类研究结果相仿。Logistic回归分析发现,女性不良反应报告率显著高于男性,接种23价肺炎球菌多糖疫苗者局部反应报告率较高,而同时接种疫苗针次未纳入回归模型。结论多种疫苗不同部位同时接种所出现的不良反应较轻微,其发生率不会因同时接种多种疫苗而增加;在中国人群中开展多种疫苗同时接种是安全可行的。
Objective To explore the safety of simultaneous vaccination of different parts of multiple vaccines in Chinese population and provide scientific basis for its further popularization. Methods From June 2004 to August 2006, applicants from the International Travel Health Care Center of Guangdong Province who were vaccinated in the United States were enrolled in the study. Subjects were recruited by self-administered questionnaires and telephone reports Adverse reactions, and with foreign research results were compared. Results Among the 772 recipients, the rate of adverse reactions was 49.6% within 7 days after inoculation. The local reaction rate was 39.8% and the systemic reaction rate was 20.1%. The results were similar to those of other foreign researches. Logistic regression analysis showed that the reporting rate of adverse reactions in females was significantly higher than that in males. The rate of local reactions in vaccinated with 23-valent pneumococcal polysaccharide vaccine was higher than that in males, while the frequency of vaccination was not included in the regression model at the same time. Conclusions Adverse reactions occurred when different vaccines were inoculated simultaneously at different sites. The incidence of multiple vaccines did not increase with simultaneous vaccination. Simultaneous vaccination of multiple vaccines was safe and feasible in Chinese population.