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本实验观测了10～30GyX线单次照射胸部后1个月大鼠的体重、肺重、体重比值、呼吸频率、组织学及肺泡Ⅱ型细胞数的变化.拟合了剂量-效应曲线.随着照射剂量增加,体重下降,肺重、体重比值上升,呼吸频率加快,肺病变比值增加及Ⅱ型细胞数增多.同时观察了照射后1个月内的死亡分布,做了肺组织超微结构观察.确定了早期放射性肺损伤的综合判定标准,并对发生机理进行了初步探讨.
In this study, we observed the changes of body weight, lung weight, body weight, respiration rate, histology and the number of type II cells in the alveolus of 1 month after single radiation of 10-30 Gy line.The dose-response curve The exposure dose increased, body weight decreased, lung weight, body weight ratio increased, respiratory rate increased, lung lesions increased and the number of type Ⅱ cells increased.At the same time, the distribution of death within 1 month after irradiation was observed, the lung tissue ultrastructure Observe.Determine the comprehensive judgment criteria of early radiation-induced lung injury, and preliminarily discuss the mechanism.