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白细胞介素2(IL-2)为活化淋巴因子激活的杀伤细胞(LAK细胞),对NK抗性的肿瘤有明显的细胞破坏作用,它是细胞免疫应答的介质,在肿瘤免疫监护系统中担负着重要作用.作者对肝细胞癌患者外周血淋巴细胞IL-2的产生能力进行了探讨.对象和方法:肝细胞癌13例,均伴肝硬化,无肝外转移;正常对照12例.经CT显象检测,按肿瘤直径分成大肿瘤(≥5cm)和小肿瘤(<5cm)两组.所有受检者的外周血淋巴细胞经分离后加入1%的PHA,37℃下培育24小时,测其上清液中IL-2活性.结果:12例正常对照者IL-2平均为0.55±
Interleukin 2 (IL-2) is activated lymphokine activated killer cells (LAK cells) and has a significant cytotoxic effect on NK-resistant tumors. It is a medium for cellular immune responses and is carried in the tumor immunological monitoring system. Important role. The authors investigated the ability of peripheral blood lymphocyte IL-2 production in patients with hepatocellular carcinoma. Object and method: 13 cases of hepatocellular carcinoma, all with cirrhosis, no extrahepatic metastasis; normal control in 12 cases. CT scans were divided into two groups: large tumors (≥5cm) and small tumors (<5cm) according to tumor diameter. Peripheral blood lymphocytes of all subjects were separated and added with 1% PHA and incubated at 37°C for 24 hours. The IL-2 activity in the supernatant was measured. Results: The average IL-2 level in 12 normal controls was 0.55±