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研究低温对颅脑损伤免疫功能的影响，探讨其亚低温颅脑损伤治疗的临床应用与监护的意义。采用流式细胞仪检测低温处理后实验型颅脑损伤大鼠外周血Ｔ细胞亚群的动态变化。结果发现，与常温对照组相比，颅脑损伤低温２７℃组ＣＤ３细胞伤后第１天，ＣＤ４细胞伤后第１天和第３天，ＣＤ４／ＣＤ８伤后第１天、第３天和第７天均降低；颅脑损伤低温３３℃组ＣＤ４细胞伤后第１天、ＣＤ４／ＣＤ８伤后第１天和第３天降低；颅脑损伤常温３７℃组ＣＤ４细胞伤后第１天、ＣＤ４／ＣＤ８伤后第１天，第３天和第７天降低。与颅脑损伤常温３７℃组相比，颅脑损伤低温２７℃组ＣＤ３细胞伤后第１天降低；颅脑损伤低温３３℃组ＣＤ４／ＣＤ８伤后第３天升高。认为重型颅脑损伤对细胞免疫功能有明显抑制作用；２７℃低温可以抑制细胞免疫功能；３３℃亚低温对细胞免疫功能不产生抑制作用
To study the effect of hypothermia on the immune function of craniocerebral injury and to explore its clinical significance and its clinical significance in the treatment of mild hypothermia craniocerebral injury. Flow Cytometry Detection of T Lymphocyte Subsets in Peripheral Blood of Rats with Experimental Brain Injury after Low Temperature Treatment. The results showed that compared with the normal control group, the traumatic brain injury at 27 ℃, the first day of injury of CD3 cells, the first day and the third day of CD4 cell injury, the first day and the third day of CD4 / CD8 injury The first day and the third day after CD4 / CD8 injury were decreased in the traumatic brain injury group. The first day and the third day after the traumatic brain injury in the 37 ℃ group, On day 1, day 3 and day 7 after CD4 / CD8 injury, they decreased. Compared with the normal temperature 37 ℃ group, the CD3 cells in the low temperature 27 ℃ group of traumatic brain injury decreased on the first day and the third day after the CD4 / CD8 injury in the 33 ℃ group. It is considered that severe craniocerebral injury has a significant inhibitory effect on cellular immune function; 27 ℃ low temperature can inhibit cellular immune function; 33 ℃ mild hypothermia has no inhibitory effect on cellular immune function