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~(131)I-胆酰甘氨酰酪氨酸(CGT)被用于裸大鼠人肝癌放射性定位和实验治疗的研究。在静注~(131)Ⅰ—CGT后所定时间内处死裸大鼠,并测定其主要脏器的放射性。~(131)Ⅰ-CGT在肿瘤中的摄取率显著地高于其他组织,特别在24h时相。注射24h后,在3只大鼠中均可见清晰的肿瘤显像。裸大鼠肝癌模型的动态扫描表明,肝癌能选择性地摄取~(131)I-CGT,并滞留达7天。经治疗的6只大鼠中,3个月后观察,其中1只鼠的肿瘤完全消退,其余的部分消退。
131I-cholanylglycyl tyrosine (CGT) was used to study the radioactive localization and experimental treatment of human hepatocellular carcinoma in nude rats. The rats were sacrificed within the time of intravenous injection of ~ (131) Ⅰ-CGT and the radioactivity of the major organs was measured. The uptake of ~ (131) I-CGT in tumors was significantly higher than that in other tissues, especially at 24h. After 24 hours of injection, clear tumor imaging was seen in all 3 rats. Dynamic scanning of a rat model of liver cancer in nude mice showed that 131 I-CGT could selectively be taken up in liver cancer for up to 7 days. Among the 6 rats treated, three months later, one of the mice completely disappeared and the remaining part subsided.