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在大鼠脊髓背角用细胞外记录技术共记录到 32个单位。角叉菜胶一侧足底注射致炎后 ,电刺激该侧足底内外侧神经激动其中A、C纤维时 ,脊髓背角神经元的诱发放电数均显著增加 ;静脉注射NMDA受体拮抗剂氯胺酮后 ,A、C纤维刺激诱发的放电反应均显著下降甚至消失。致炎后脊髓背角深层单位出现Windup现象 ,静脉注射氯胺酮后该现象减轻或消失。结果提示 :角叉菜胶致炎导致脊髓背角神经元兴奋性升高和Windup ;NMDA受体参与炎症痛和Windup形成。
A total of 32 units were recorded in the spinal dorsal horn using extracellular recording techniques. Carrageenan side of the foot after injection of inflammation, electrical stimulation of the side of the lateral medial and lateral nerve stimulation in which A, C fibers, the firing rate of spinal dorsal horn neurons were significantly increased; intravenous NMDA receptor antagonist Ketamine, A, C fiber-induced discharge response were significantly decreased or even disappear. After the inflammation of the spinal cord dorsal horn appeared deep units Windup phenomenon, intravenous injection of ketamine to reduce or disappear after the phenomenon. The results suggest that carrageenin-induced inflammation leads to increased excitability of the spinal dorsal horn neurons and Windup; NMDA receptors are involved in inflammatory pain and Windup formation.