我院收治系统性硬皮病2例,采用青霉胺治疗后达到临床治愈。现报告如下。例1:女,29岁,已婚,颜面、四肢、皮肤逐渐变硬5年余.持续发热70余天,于1985年3月11日入院。患者身体一向健康,生育一女周岁,双亲非近亲配。体检:T39.8℃,P102次/分,BP16/9.3KPa,慢性病容,面容刻板,眼睑不能完全闭合,张口仅1.5cm,心 2 cases of systemic scleroderma were treated in our hospital, and clinical cure was achieved after treatment with penicillamine. The report is as follows. Example 1: Female, 29 years old, married, face, limbs, skin gradually harden more than 5 years. Sustained fever more than 70 days, on March 11, 1985 admission. The patient’s body has always been healthy, one year-old childbearing, parents with non-close relatives. Physical examination: T39.8 ℃, P102 / min, BP16 / 9.3KPa, chronic disease, face stereotypes, eyelids can not be completely closed, mouth only 1.5cm, heart