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目的 研究BMP2mRNA在颌骨骨肉瘤及软骨肉瘤中的扩增及其对肿瘤预后和增殖活性的影响。方法 应用BMP2的cDNA探针 ,原位杂交检测mRNA的扩增。结果 32例标本中有 2 1例表达BMP2mRNA ,有BMP2mRNA表达的病例更容易发生淋巴结转移 ,且有较高增殖活性。结论 BMP2可能在骨肿瘤的发生和发展过程中起一定作用 ,可以作为估计骨肉瘤预后的参考指标
Objective To study the proliferation of BMP2 mRNA in osteosarcoma and chondrosarcoma of the jaw and its effect on the prognosis and proliferative activity of the tumor. Methods BMP2 cDNA probe was used to detect the mRNA amplification by in situ hybridization. Results Of the 32 specimens, 21 cases expressed BMP2 mRNA. Cases with BMP2 mRNA expression were more likely to have lymph node metastasis and had higher proliferative activity. Conclusion BMP2 may play a role in the occurrence and development of bone tumors and can be used as a reference for estimating the prognosis of osteosarcoma.