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目的:研究乳腺癌保留乳房手术术后复发的相关危险因素。方法:回顾分析我院2000-01-2005-12行乳腺癌保留乳房手术289例,将其中术后局部复发的35例与无复发病例进行临床与病理对比分析,寻找临床病理资料相关危险因子。结果:复发组与未复发组相比,患者的年龄较小(P<0.01),肿瘤体积较大(P<0.01),肿瘤距乳头距离较近(P<0.01),ER及PR阴性率较高(P<0.01),Her-2过表达率较高(P<0.01),有乳腺癌家族史比例较高,P<0.01。而手术方式、病理类型、淋巴结数目、组织学分级、术后化疗与放疗等方面则差异无统计学意义。结论:对于乳腺癌保留乳房手术,应该个体化综合评价可能引起复发的各项危险因素,选择适当与规范的治疗方案,从而获得满意的治疗效果。
Objective: To study the risk factors of breast cancer recurrence after breast surgery. Methods: A retrospective analysis of our hospital from 2000-01-2005-12 breast conserving breast surgery in 289 cases, including 35 cases of postoperative recurrence and no recurrence of clinical and pathological comparative analysis of clinical and pathological data to find the relevant risk factors. Results: Compared with the non-recurrence group, the patients were younger (P <0.01), tumor volume was larger (P <0.01), and tumor was closer to the nipple (P <0.01) (P <0.01). The overexpression rate of Her-2 was higher (P <0.01) and the proportion of family history of breast cancer was higher (P <0.01). The surgical methods, pathological types, the number of lymph nodes, histological grade, postoperative chemotherapy and radiotherapy, the difference was not statistically significant. Conclusion: Breast cancer retention breast surgery should be a comprehensive evaluation of individual risk factors that may lead to recurrence, select the appropriate and standardized treatment options, so as to obtain satisfactory results.