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美国得克萨斯儿童医院1974～1979年间共收容脑脊液细菌培养证实的B族链球菌(GBS)脑膜炎61例,13例于住院过程中死亡,早期病死率为21.3％。分析逐年病死率,前三年为48％,后三年为10％,说明早期病死率逐渐下降(P<0.01)。为了确定疾病对存活患儿的长期影响,作者将出院后失去联系的10例剔除,对51例GBS脑膜炎的远期转归及其与急性期临床表现之间的关系进行了详尽的随访研究。 51例中14例为早发型脑膜炎,起病于
Between 1974 and 1979, the Texas Children’s Hospital of the United States housed 61 cases of B-streptococcal (GBS) meningitis confirmed by bacterial culture of cerebrospinal fluid, and 13 died of hospitalization with an early mortality rate of 21.3%. Analysis of annual mortality, 48% in the first three years, 10% in the latter three years, indicating that early mortality decreased gradually (P <0.01). In order to determine the long-term effects of the disease on surviving children, the authors excluded 10 patients who lost contact after discharge and conducted a detailed follow-up study of the long-term outcome of 51 GBS meningitis cases and their association with acute phase clinical manifestations . Of the 51 cases, 14 were early-onset meningitis, with onset