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鼻用糖皮质激素是缓解鼻-鼻窦炎症状的主要药物。近年来,随着对糖皮质激素作用机制研究的不断深入,已经明确糖皮质激素受体(GR)是糖皮质激素发挥生理和药理作用的中介物。作者就GR的基因及其产物GRα和GRβ的表达、调节以及在鼻-鼻窦炎性疾病中的变化与意义作一综述。
Nasal glucocorticoid is the main drug to relieve the symptoms of rhinosinusitis. In recent years, with the continuous research on the mechanism of action of glucocorticoids, it has been clear that glucocorticoid receptor (GR) is an intermediate of glucocorticoid exerting physiological and pharmacological effects. The authors review the expression and regulation of the GR gene and its products, GRα and GRβ, as well as their significance in the pathogenesis of nasal-sinusitis.