论文部分内容阅读
目的观察缺氧缺血性脑病(HIE)新生儿血清血管内皮生长因子(VEGF)、IL-18表达,探讨其在HIE中的临床意义。方法足月HIE患儿60例(轻度13例,中度30例,重度17例)及38例健康足月新生儿(健康对照组)分别于出生72h取静脉血,采用ELISA法检测血清VEGF及IL-18水平,比较各组间的差异;并分析HIE患儿VEGF与IL-18水平的相关性。结果 1.HIE组血清VEGF水平及IL-18表达水平显著高于健康对照组(P均<0.01);2.HIE各组血清VEGF水平及IL-18表达水平随HIE程度加重而增加,各组间差异均有统计学意义(P均<0.05);3.HIE患儿血清VEGF水平及IL-18水平呈正相关(r=0.867,P<0.05)。结论血清VEGF与IL-18表达水平可作为HIE新生儿病情严重程度早期指标;HIE的发生、发展可能是多因素联合参与的过程,其中免疫、神经内分泌系统的变化及炎症反应等异常同步发生,相互关联。
Objective To observe the expression of serum vascular endothelial growth factor (VEGF) and interleukin-18 (IL-18) in neonates with hypoxic-ischemic encephalopathy (HIE) and to explore its clinical significance in HIE. Methods Sixty children with mild HIE (mild 13, moderate 30, severe 17) and 38 healthy full-term newborns (healthy control) were enrolled in this study. Serum VEGF And IL-18 levels were compared between groups, and the correlation between VEGF and IL-18 levels was analyzed. Serum levels of VEGF and IL-18 in HIE group were significantly higher than those in healthy control group (all P <0.01). 2. Serum levels of VEGF and IL-18 in HIE group increased with the increase of HIE level, (P <0.05). 3. Serum VEGF level and IL-18 level in HIE children were positively correlated (r = 0.867, P <0.05). Conclusions Serum levels of VEGF and IL-18 may serve as early indicators of the severity of neonatal HIE. The occurrence and development of HIE may be involved in many factors, including immune, neuroendocrine system changes and inflammatory reactions. Interrelated.