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胰腺癌术中放疗是在术中将胰腺肿物充分显露后,对肿瘤进行一次性肿瘤致死量放射治疗,用以缓解疼痛,延长生存期,减少体外放疗的并发症。早在1909年,Beck报道了在胃癌及结肠癌手术中,将不能切除的肿物托到伤口外放射治疗。1915年,Finsterer开始在术中对胃癌行放疗。30年代,Eloesser在术中用大剂量放射线治疗腹腔内肿物,他认为早期效果好,无明显并发症。40年代,Ellis在术中应用直线加速器,但未能推广。1959年、Barth等人开始联合应用术中放疗及体外放疗治疗胰腺癌。虽然早期术中放疗未能广泛应用,但经验提示术中放疗可用大剂量放射线治疗腹腔内肿物,并发症少,且可与体外放疗联合应用。
Intraoperative radiotherapy for pancreatic cancer is the full disclosure of pancreatic tumors during surgery. The tumors are given a one-time lethal dose of radiotherapy to relieve pain, prolong survival, and reduce the complications of external radiotherapy. As early as 1909, Beck reported that in the treatment of gastric cancer and colon cancer, the unresectable tumor was placed on the external radiotherapy. In 1915, Finsterer began radiotherapy for gastric cancer during surgery. In the 1930s, Elosesser used high-dose radiation to treat intra-abdominal masses during surgery. He believed that the early results were good and there were no obvious complications. In the 1940s, Ellis applied linear accelerators during surgery but failed to promote it. In 1959, Barth et al. began a combination of intraoperative radiotherapy and in vitro radiotherapy for pancreatic cancer. Although early intraoperative radiotherapy has not been widely used, experience has shown that intraoperative radiotherapy can use large doses of radiation to treat intra-abdominal masses with few complications and can be used in combination with external radiotherapy.