目的探讨不同胃疾病患者血清ｈＥＧＦ含量变化的临床意义．方法用ＲＩＡ法测定慢性胃炎（ＣＧ）患者５５例，胃癌（ＧＣ）患者１３例及胃溃疡（ＧＵ）患者１１例血清人表皮生长因子（ｈＥＧＦ）含量，并与２１例正常健康人对照分析．结果与正常人血清ｈＥＧＦ含量（０７８μｇ／Ｌ±０２７μｇ／Ｌ）比较，ＣＧ患者血清ｈＥＧＦ含量显著升高（１５８μｇ／Ｌ±０２０μｇ／Ｌ，Ｐ＜００５），ＧＵ患者ｈＥＧＦ含量明显降低（０４５μｇ／Ｌ±０１３μｇ／Ｌ，Ｐ＜００５），而ＧＣ患者ｈＥＧＦ含量则无明显变化（１１７μｇ／Ｌ±０３３μｇ／Ｌ，Ｐ＞００５）．按慢性胃炎病变程度比较见慢性浅表性胃炎（ＣＳＧ）、轻度及中、重度慢性萎缩性胃炎（ＣＡＧ）患者血清ｈＥＧＦ均高于正常人（１４９μｇ／Ｌ±０３７μｇ／Ｌ，１５２μｇ／Ｌ±０３５μｇ／Ｌ及１６６μｇ／Ｌ±０２８μｇ／Ｌ与０７８μｇ／Ｌ±０２７μｇ／Ｌ，Ｐ＜００５），且随着病变程度的加重，ｈＥＧＦ含量有升高的趋势．结论慢性胃炎、胃溃疡患者ｈＥＧＦ含量异常与其发病及病理过程密切相关． Objective To investigate the clinical significance of serum hEGF levels in patients with different gastric diseases. Methods The levels of serum human epidermal growth factor (hEGF) in 55 patients with chronic gastritis (CG), 13 patients with gastric cancer (GC) and 11 patients with gastric ulcer (GU) were measured by RIA. The results were compared with 21 normal healthy controls. Results Compared with normal human serum hEGF levels (078μg/L±027μg/L), serum hEGF levels in CG patients were significantly increased (158μg/L±020μg/L, P<005). The hEGF content in GU patients significantly decreased (045μg/L±013μg/L, P<005), while the hEGF content in GC patients had no significant changes (117μg/L±033μg/L, P> 005). According to the chronic gastritis lesions, the serum hEGF in patients with chronic superficial gastritis (CSG) and mild and moderate and severe chronic atrophic gastritis (CAG) were higher than those in normal people (149μg/L±037μg/L). 152μg/L±035μg/L and 66μg/L±028μg/L and 0.7μg/L±27μg/L, P<005), and aggravated with the severity of the disease , hEGF content has a rising trend. Conclusion The abnormal hEGF level in patients with chronic gastritis and gastric ulcer is closely related to its pathogenesis and pathogenesis.