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目的研究6种抗癌剂对奥丹西酮药动学的影响。方法奥丹西酮的药动学在21例分别应用甲氨蝶呤、5 -氟尿嘧啶、环已亚硝脲、环磷酰胺和长春新碱、顺氯氨铂的原发性肺癌患者中进行观察 ,化疗前和化疗同时服用奥丹西酮 ,其血浆浓度采用反相高效液相色谱法测定。数据处理采用PKBP -N1程序。结果奥丹西酮吸收快 ,并符合二房室模型 ,除单/大剂量冲击疗法 ,持续应用抗癌药物均使其药动学参数发生明显变化 ,T1/2β 延长约1h ,T1/2α 发生不规则变化 ,Cmax 和AUC也明显升高 ,但Tmax 和T1/2ka 长期用药将发生体内蓄积。结论临床应用奥丹西酮防治化疗所致胃肠道反应时 ,应据患者条件和化疗方案调整给药
Objective To study the effect of six anticancer agents on the pharmacokinetics of ondansetron. Methods Pharmacokinetics of ondansetron was observed in 21 patients with primary lung cancer who were treated with methotrexate, 5-fluorouracil, nitrosourea, cyclophosphamide, vincristine, and cisplatin, respectively. Before and after chemotherapy, ondansetron was taken and the plasma concentration was measured by RP-HPLC. Data processing uses the PKBP-N1 program. Results Ondansetron was absorbed rapidly and was consistent with a two-compartment model. In addition to single-dose/high-dose impingement therapy, the continuous application of anticancer drugs resulted in significant changes in pharmacokinetic parameters. T1/2β was prolonged for approximately 1 h, and T1/2α was not detected. Changes in the rules, Cmax and AUC also increased significantly, but long-term use of Tmax and T1/2ka will accumulate in the body. Conclusion The clinical application of ondansetron in the prevention and treatment of gastrointestinal reactions caused by chemotherapy should be adjusted according to the patient’s condition and chemotherapy regimen.