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尿毒症周围神经病是以肢体远端对称性感觉障碍为主的多发性周围神经病变,给患者带来极大的痛苦。主要通过对它的中医认识和发病机制及治疗进行深入研究,中医认为尿毒症的病机错综复杂,虚实并见、阴阳失调、湿毒化热、寒热交错等都可以出现,而周围神经病变则属中医学“痹证”范围,病性总归本虚标实。发病机制主要有中分子物质,神经转酮酶活性抑制,肌醇,胍类化合物,酚,液体电解质渗透压变化,营养不良,碳水化合物代谢紊乱,营养神经血管病变及内分泌功能紊乱。治疗手段分别为血液灌流或血液透析滤过,营养支持,血管活性药物,纠正水电解质酸碱平衡,内服中药汤剂中药灌肠及针灸。
Uremia Peripheral neuropathy is a multiple peripheral neuropathy characterized by distal symmetrical sensory disturbances, which brings great suffering to patients. Mainly through its understanding of Chinese medicine and pathogenesis and treatment in-depth study, Chinese medicine that the pathogenesis of uremia is complex, the actual situation and see, yin and yang imbalance, wet poisoning fever, cold and heat staggered, etc. can occur, while the peripheral neuropathy is in the Medical “Arthralgia ” range, the disease always empty the mark. The main pathogenesis of molecular substances, inhibition of neurotransmitter activity, inositol, guanidine compounds, phenol, liquid electrolyte osmotic pressure changes, malnutrition, carbohydrate metabolism disorders, nutritional neurovascular disease and endocrine disorders. Treatment were hemoperfusion or hemodiafiltration, nutritional support, vasoactive drugs, correct water and electrolyte acid-base balance, oral administration of traditional Chinese medicine decoction enema and acupuncture.