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目的:探讨维吾尔族健康人群肾功能增龄改变与增强指数的关系。方法:从新疆和田地区筛选临床健康居民638人,检测血压、血肌酐等指标,用中国人校正的MDRD公式计算估算肾小球滤过率,用澳大利亚PWA仪测定增强指数。结果:随着年龄增长,肾功能随增龄减退,增强指数随增龄增高,尤其是>60岁人群;肾功能及增强指数的增龄改变存在性别差异;在各年龄组中,女性增强指数升高更明显;高增强指数人群比低增强指数人群年龄偏大,肾功能减退明显,多元逐步回归分析显示估算肾小球滤过率和增强指数呈负相关。结论:增强指数和肾功能的生理性衰退相关。
Objective: To investigate the relationship between increasing renal function and enhancing index of Uygur healthy population. Methods: A total of 638 healthy residents were enrolled in the Hetian area. Blood pressure and serum creatinine were measured. The glomerular filtration rate (GFR) was calculated by Chinese MDRD formula and the augmentation index was measured by Australian PWA instrument. Results: As the age increased, the renal function decreased with age, and the enhancement index increased with age, especially in the population aged> 60 years. There was a gender difference in the age-related changes of renal function and enhancement index. In all age groups, Higher than those in the low enhancement index population. The multiple regression analysis showed that the estimated glomerular filtration rate and the enhancement index were negatively correlated. Conclusions: The enhancement index correlates with the physiological decline of renal function.