意大利Biocine公司的研究人员研制出一种口服菌苗,能在鼠模型中抗幽门螺杆菌感染。据信胃幽门螺杆菌感染实际上可引起所有十二指肠溃疡,且与胃腺癌有关。幽门螺杆菌至少有两型,十二指肠溃疡患者通常感染的是I型细菌。 研究人员以致空泡细胞毒素（VacA）免疫小鼠,并与脲酶和安慰剂相比较。VacA是I型幽门螺杆菌的特异性抗原,引起上皮细胞空泡形成。与佐剂一起接种后,VacA菌苗使78.6％的小鼠免受I型菌株感染,脲酶组保护率为84.6％,安慰剂组小鼠未见保护作用。同时将VacA作为抗无细胞毒性的Ⅱ型幽门螺杆菌菌苗进行研究。发现VacA不能使小鼠免受Ⅱ型幽门螺杆菌感染。 Researchers at Biocine in Italy have developed an oral vaccine that can infect Helicobacter pylori in a murine model. Helicobacter pylori infection is believed to actually cause all duodenal ulcers and is associated with gastric adenocarcinoma. Helicobacter pylori at least two types, duodenal ulcer patients are usually infected with type I bacteria. The researchers immunized mice with vacuolar cytotoxin (VacA) and compared it with urease and placebo. VacA is a specific antigen of Helicobacter pylori I, causing vacuolar epithelial cells to form. After vaccination with the adjuvant, VacA vaccine prevented 78.6% of mice from being infected with the type I strain. The protective rate was 84.6% in the urease group and no protective effect in the placebo group. VacA was also studied as a non-cytotoxic class II Helicobacter pylori vaccine. VacA was found to not protect mice from Helicobacter pylori type II infection.