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红霉素是一个相当安全并广泛应用的抗生素,以往认为是无肾毒性的。本文报道1例红霉素所致急性间质性肾炎,并为肾活检所证实。患者39岁女性,因贫血全身虚弱入院。6岁时曾患风湿热,过去几年中情况良好,偶而在上呼吸道感染时对症处理。曾用可待因、安基比林、非那西丁等。入院前几周因扁桃体炎复发而服用红霉素。入院时除明显贫血外,唯一阳性体征为主动脉喷射音和心尖部舒张期杂音。血象中嗜酸性细胞不高。ESR 50mm/h,Hb 7.3g/dl,白细胞9300/mm~3,血小板10万/mm~3,BUN 73.4mg/dl、Cr 6.1mg/dl,
Erythromycin is a fairly safe and widely used antibiotic, which in the past was considered nephrotoxic. This article reports 1 case of erythromycin-induced acute interstitial nephritis, and confirmed by renal biopsy. 39-year-old female patient admitted to hospital due to anemia. 6 years old had rheumatic fever, the past few years in good condition, and occasionally symptomatic treatment of upper respiratory tract infection. Had codeine, 安基比林, phenacetin and so on. A few weeks before admission due to recurrence of tonsillitis and taking erythromycin. Addition to significant anemia on admission, the only positive signs of aortic jet sound and apical diastolic murmur. Blood eosinophilic cells are not high. ESR 50 mm / h, Hb 7.3 g / dl, white blood cells 9300 / mm ~ 3, platelets 100,000 / mm ~ 3, BUN 73.4 mg / dl, Cr 6.1 mg /