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目的 :检测急性心肌梗死患者可溶性细胞间粘附分子 1 (sICAM 1 )的变化 ,探讨其在急性心肌梗死发病机制、病情监测中的意义。方法 :用酶联免疫吸附法检测 5 0例急性心肌梗死 (AMI) ,30例健康者血浆sICAM 1水平。结果 :①AMI患者sICAM 1水平较正常对照组高 (P <0 .0 1 )。②AMI患者按心功能分组 ,各组间有显著差异。结论 :ICAM 1参与了急性心肌梗死的发病过程 ,并可作为病情监测指标。
Objective: To detect the changes of soluble intercellular adhesion molecule - 1 (sICAM 1) in patients with acute myocardial infarction (AMI) and to explore its significance in the pathogenesis and monitoring of acute myocardial infarction. Methods: Serum levels of sICAM 1 in 50 AMI and 30 healthy controls were detected by enzyme-linked immunosorbent assay. Results: ① The level of sICAM 1 in patients with AMI was higher than that in controls (P <0.01). ② AMI patients according to cardiac function group, there are significant differences between the groups. Conclusion: ICAM 1 participates in the pathogenesis of acute myocardial infarction.