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目的研究大剂量酮洛芬（Ｋｅｔ）、吲哚美辛（Ｉｎｄ）致小鼠胃粘膜损伤及其与胃组织中前列腺素（ＰＧ）、氧自由基（ＯＦＲ）及一氧化氮（ＮＯ）含量的关系。方法①测定小鼠胃粘膜损伤指数；②测定胃组织ＰＧＥ２、ＭＤＡ含量；③测定血浆、胃组织中ＮＯ含量。结果１６，３２ｍｇ·ｋｇ－１Ｋｅｔ和Ｉｎｄ均能引起小鼠胃粘膜损伤，Ｉｎｄ的致损伤作用更为显著。Ｋｅｔ和Ｉｎｄ组胃组织中ＰＧＥ２、ＭＤＡ含量较对照组降低，而ＮＯ含量显著增高。结论大剂量Ｋｅｔ、Ｉｎｄ可致胃粘膜损伤，且Ｋｅｔ引起的损伤程度较轻；胃组织内ＰＧＥ２含量降低和ＮＯ含量异常增高可能是Ｋｅｔ和Ｉｎｄ致胃粘膜损伤的重要机制。
Objective To investigate the effects of high dose ketamine (Ket) and indomethacin (Ind) on gastric mucosal lesion and its relationship with the content of prostaglandin (PG), oxygen free radical (OFR) and nitric oxide Relationship. Methods ① Gastric mucosal injury index was measured in mice. ② The content of PGE2 and MDA in gastric tissue was measured. ③ The content of NO in plasma and gastric tissue was determined. Results Both 16 and 32 mg · kg-1 Ket and Ind were able to cause gastric mucosal injury in mice, and Ind-induced injury was more significant. The levels of PGE2 and MDA in gastric tissue in Ket and Ind groups were lower than those in control group, while the content of NO was significantly increased. Conclusions Ket and Ind can cause gastric mucosal injury at high dose and less damage caused by Ket. The decrease of PGE2 and the abnormal increase of NO in gastric tissue may be the important mechanism of gastric mucosal injury induced by Ket and Ind.