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目的:探讨瘦素(Leptin)与钙、磷、血清骨碱性磷酸酶(BAP)及骨形成标志物骨钙素(OC)和骨吸收标志物胶原分解片段(β-CTx)等骨营养代谢指标的相关性,了解晚期早产儿骨营养代谢特点,提供临床早期监测骨营养代谢的敏感指标。方法:选择2013年1月-2014年1月期间我科收治的日龄≤28天晚期早产儿100例为病例组;同期住院的日龄≤28天足月儿(37周<胎龄≤42周)50例为对照组,采集外周血5ml,采用日立7060全自动生化仪检测血清Ca2+、P的水平;采用酶联免疫方法(ELISA)测定:Leptin、OC、β-CTx、BAP等指标水平。结果:病例组及对照组Ca2+分别为1.99±0.13mmol/L、2.11±0.19mmol/L,P分别为1.52±0.18mmol/L、1.58±0.19mmol/L,OC分别为47.56±14.72ug/L、46.66±10.61ug/L,P>0.05,差异无统计学意义;病例组及对照组BAP分别为209.19±40.89u/L、162.41±41.47u/L,β-CTx分别为1.10±0.32ng/L、0.83±0.30ng/L,Leptin分别为1.25±0.70ng/L、3.28±1.53ng/L,P<0.05,差异有统计学意义;两组Leptin与β-CTx、BAP之间相关性研究显示P>0.05,无相关性。结论:BAP、β-CTx、Leptin水平在晚期早产儿与足月儿相比,胎龄越小,β-CTx和BAP水平越高,Leptin水平越低,BAP、β-CTx、Leptin可作为早期诊断晚期早产儿代谢性骨病的敏感指标,而Leptin与BAP、β-CTx在晚期早产儿无相关性。
Objective: To explore the relationship between leptin and calcium, phosphorus, bone alkaline phosphatase (BAP), osteocalcin (OC), and β-CTx, Indicators related to understand the characteristics of late-term preterm infants nutritional bone metabolism to provide early clinical monitoring of bone nutrition metabolism sensitive indicators. Methods: 100 cases of premature infants ≤ 28 days of age treated in our department from January 2013 to January 2014 were selected as case group; the hospitalized patients were ≤28 days of full-term infants (37 weeks 0.05, the BAP was 209.19 ± 40.89u / L and 162.41 ± 41.47u / L respectively in the case group and the control group, and the values of β-CTx were 1.10 ± 0.32ng / L, 0.83 ± 0.30ng / L, Leptin respectively 1.25 ± 0.70ng / L, 3.28 ± 1.53ng / L, P <0.05, the difference was statistically significant; Correlation between Leptin and β-CTx, BAP Show P> 0.05, no correlation. Conclusion: Compared with full-term infants, BAP, β-CTx and Leptin levels are lower in gestational age, higher levels of β-CTx and BAP, lower levels of Leptin, BAP, β-CTx and Leptin can be used as early Diagnosis of advanced metabolic syndrome in preterm children sensitive indicators, and Leptin and BAP, β-CTx no correlation in advanced preterm children.