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目的通过急性毒性试验验证逐痰消痹方贴剂的毒理学安全性。方法 1急性毒性:以不同剂量的逐痰消痹方贴剂贴到豚鼠的完整和破损皮肤,观察豚鼠的体质量、活动、死亡率等;2皮肤刺激性:在家兔的完整和破损皮肤上贴不同剂量的药物,观察红斑、水肿等;3皮肤过敏性:在豚鼠的完整皮肤上贴不同剂量的药物以及阳性对照药物,观察过敏、全身变态反应等。结果急性毒性试验显示豚鼠全身无异常变化,未见死亡,皮肤刺激性试验和皮肤毒性试验显示豚鼠涂药部位没有红肿、炎症、溃烂、坏死等现象。结论逐痰消痹方贴剂经皮肤给药安全,无毒性。
Objective To verify the toxicological safety of Phlegm-Xiaoti patch by acute toxicity test. Method 1 Acute Toxicity: Apply different doses of phlegm Xiaobu patch to whole and broken skin of guinea pig, and observe the body weight, activity and mortality of guinea pig; 2 Skin Irritation: Complete and damaged skin in rabbits Different doses of drugs posted on the observation of erythema, edema, etc .; 3 skin allergies: guinea pigs with intact skin paste different doses of drugs and positive control drugs to observe allergies, systemic allergies. Results Acute toxicity test showed no abnormal changes in the body of guinea pigs. No death was observed. Skin irritation test and skin toxicity test showed no signs of swelling, inflammation, ulceration and necrosis in guinea pigs. Conclusion Phlegm Xiaobi patch through the skin safe, non-toxic.