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三七花总皂甙50～100mg/kg ip能明显抑制鹿角菜胶、5HT、高岭土等所致大鼠脚爪水肿和巴豆油所致小鼠耳廓肿胀,并能显著对抗5HT、组织胺及缓激肽所致大鼠皮肤毛细血管通透性的增加,还可减少炎症渗出物中的PGE含量。切除双侧肾上腺后,三七花总皂甙对角叉菜胶性大鼠脚肿仍有显著抑制作用。但对大鼠肾上腺中维生素C含量无明显影响,提示其抗炎作用可能不依赖于垂体—肾上腺系统,而与抑制前列腺素合成有关。
Notoginseng flower saponins 50 ~ 100mg/kg ip can significantly inhibit rat paw edema caused by carrageenan, 5HT, kaolin, etc., and croton oil-induced mouse ear swelling, and can significantly resist 5HT, histamine and deferred stimulation. Increased capillary permeability of rat skin caused by peptides can also reduce PGE content in inflammatory exudates. After excision of bilateral adrenal glands, total saponins of Panax notoginseng still showed significant inhibitory effects on paw swelling in carrageenan rats. However, there was no significant effect on the content of vitamin C in the rat adrenal gland, suggesting that its anti-inflammatory effects may not be dependent on the pituitary-adrenal system but related to inhibition of prostaglandin synthesis.