干细胞的旁分泌机制已被认为是促进梗死区心肌再生、修复损伤心肌细胞的主要途径。随着进一步的深入研究,发现分泌型卷曲相关蛋白2(secreted frizzled-related protein 2,Sfrp 2)与干细胞的旁分泌机制有着密切的联系,它通过竞争结合Wnt信号通路的特异性卷曲受体(Fz),从而抑制Wnt通路的信号传导,调控细胞的凋亡、分化等生命过程,成为近年来研究的热点。我们就Sfrp 2通过Wnt信号途径参与调节干细胞治疗心肌梗死的机制作一综述。 Paracrine mechanism of stem cells has been considered to promote myocardial regeneration in infarction area, the main way to repair damaged myocardial cells. With further studies, we found that secreted frizzled-related protein 2 (Sfrp 2) is closely related to the paracrine mechanism of stem cells by competing with specific coiled receptors that bind to the Wnt signaling pathway Fz), thus inhibiting Wnt signaling pathway, regulating cell apoptosis, differentiation and other life processes, has become a hot research in recent years. We review the mechanism by which Sfrp 2 participates in the regulation of stem cell therapy of myocardial infarction through the Wnt signaling pathway.