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目的研究血清性激素、胰岛素水平与不孕的关系。方法筛选120名不孕妇女,其中多囊卵巢综合征(PCOS)48例,非 PCOS 不孕妇女72例为实验组,测定血清黄体激素(LH),睾硐(T)卵泡刺激素(FSH),雌二醇(E_2),空腹胰岛素(FINS),空腹血糖(FBG),并计算出胰岛素抵抗指数(HOMA-IR)。另设50名正常生育妇女作对照组。结果(1)不孕组血清 LH、T、FINS 及 HOMA-IR 明显增高,FSH、E_2和 ISI 明显下降(P<0.01=);(2)与非 PCOS 组比较,PCOS 组 FINS、LH 和 T 明显增高,E_2、ISI 明显下降(P<0.01=);LH/FSH 比值也明显高于非 PCOS 组(P<0.01=);(3)不孕组的血清 T 水平与 INS,HOMA-IR 及呈正相关,与 ISI 呈负相关(P<0.05=),E_2水平与 INS、HOMA-IR 呈负相关,与 ISI 呈正相关(P<0.05=)。结论不孕妇女血清性激素水平异常,胰岛素抵抗尤其是 PCOS 患者表现为高胰岛素血症,高雄激素血症。
Objective To study the relationship between serum sex hormones and insulin levels and infertility. Methods A total of 120 infertile women were screened, including 48 cases of polycystic ovary syndrome (PCOS) and 72 cases of non-PCOS infertile women. Serum levels of LH, T FSH, (E2), fasting insulin (FINS), fasting blood glucose (FBG), and calculate the insulin resistance index (HOMA-IR). Another 50 normal fertility women as a control group. Results (1) Serum levels of LH, T, FINS and HOMA-IR in infertility group were significantly increased, but FSH, E_2 and ISI were significantly decreased (P <0.01); (2) Compared with non-PCOS group, FINS, LH and T (P <0.01), and the ratio of LH / FSH was significantly higher than that of non-PCOS group (P <0.01); (3) The serum T level in infertility group was significantly higher than that in INS, HOMA-IR and (P <0.05). The level of E_2 was negatively correlated with INS and HOMA-IR, and positively correlated with ISI (P <0.05 =). Conclusion Infertile women have abnormal serum sex hormone levels. Insulin resistance, especially PCOS, is characterized by hyperinsulinemia and hyperandrogenism.