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目的探讨消化系统淀粉样变病的临床表现和诊治手段,提高对该病的诊断准确率,避免误诊。方法收集消化系统淀粉样变病患者11例,对病变的分布、分类、临床表现、诊断、治疗及预后进行分析、归纳和总结。结果消化系统淀粉样变病最常累及肝脏,其次为胃肠道及脾;该病临床表现多样,确乏特异性,误诊率高达36.4%;系统性淀粉样变病预后很差,多死于消化道大出血,而局限性淀粉样变病预后相对较好。结论肝脏是消化系统淀粉样变病最常侵犯的脏器之一,及时活检可以避免误诊,改善病人的预后。
Objective To investigate the clinical manifestations and diagnosis and treatment of amyloidosis in digestive system and to improve the diagnostic accuracy of the disease and avoid misdiagnosis. Methods Eleven patients with amyloidosis in digestive system were collected and their distribution, classification, clinical manifestation, diagnosis, treatment and prognosis were analyzed and summarized. Results The digestive system amyloidosis most often involved the liver, followed by the gastrointestinal tract and the spleen. The clinical manifestations of the disease were diverse and lacking in specificity. The misdiagnosis rate was as high as 36.4%. The prevalence of systemic amyloidosis was poor, Gastrointestinal bleeding, and limitations of amyloidosis prognosis is relatively good. Conclusion The liver is one of the most frequently invaded organs of digestive system amyloidosis. Timely biopsy can avoid misdiagnosis and improve patient prognosis.