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树突状细胞(DC)在免疫反应中发挥重要作用,Notch信号通路在胚胎期和出生后的发育过程中调节细胞增殖、分化和凋亡。Notch信号参与了DC发育分化及其功能调控,本文综述了Notch信号与DC发育分化、功能调控的研究进展。
Dendritic cells (DCs) play an important role in the immune response. The Notch signaling pathway regulates cell proliferation, differentiation and apoptosis during embryonic and postnatal development. Notch signaling is involved in the development and differentiation of DC and its function regulation. This review summarizes the progress of the development and differentiation and regulation of Notch signaling and DC.