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目的评价替考拉宁对社区获得性耐甲氧西林金黄色葡萄球菌感染的作用研究,为临床合理用药提供依据。方法收集2007年7月-2009年3月青岛市市立医院社区获得性金黄色葡萄球菌感染患者55例,包括肺炎10例、脓毒血症3例、伤口感染38例、泌尿系感染4例,第1天给予替考拉宁400 mg静脉滴注,1次/12 h,之后400 mg/d,疗程7～21 d,观察疗效和安全性。结果替考拉宁治疗后,患者痊愈47例,显效3例,总有效率90.9%,不良反应发生2例,发生率3.6%。结论替考拉宁对社区获得性耐甲氧西林金黄色葡萄球菌具有较强的抗菌活性,在治疗社区获得性耐甲氧西林金黄色葡萄球菌感染中有好的临床前景,不良反应相对较低,使用安全、方便。
Objective To evaluate the effect of teicoplanin on community-acquired methicillin-resistant Staphylococcus aureus (SCN) infection in order to provide a basis for clinical rational drug use. Methods 55 cases of community-acquired S. aureus infection in Qingdao Municipal Hospital from July 2007 to March 2009 were collected, including 10 cases of pneumonia, 3 cases of sepsis, 38 cases of wound infection, 4 cases of urinary tract infection, On the first day, teicoplanin 400 mg was given intravenously, once / 12 h, then 400 mg / d, for 7-21 d. The curative effect and safety were observed. Results Teicoplanin treatment, the patient recovered in 47 cases, markedly effective in 3 cases, the total effective rate was 90.9%, adverse reactions occurred in 2 cases, the incidence rate of 3.6%. CONCLUSION Teicoplanin has strong antibacterial activity against community-acquired methicillin-resistant Staphylococcus aureus and has good clinical prospects in the treatment of community-acquired methicillin-resistant Staphylococcus aureus infections with relatively low adverse reactions Use safe and convenient.