感染、休克、缺血、缺氧等病理过程中,细胞内钙聚积被认为是细胞不可逆损伤的共同通路。在这些病理过程中,氧自由基引起的膜脂质过氧化损伤也具有重要的发病学意义。本工作观察钙通道阻滞剂异搏定对内毒素血症大鼠心肌、肝脏组织膜脂质过氧化和钙含量的影响,以探讨细胞内钙聚积和脂质过氧化的关系。 Infection, shock, ischemia, hypoxia and other pathological processes, intracellular calcium accumulation is considered the common pathway of irreversible cell damage. In these pathological processes, oxygen free radicals caused by membrane lipid peroxidation damage also has important significance of the disease. This study was to investigate the effect of verapamil, a calcium channel blocker, on lipid peroxidation and calcium content in myocardium and liver tissue of endotoxemic rats to explore the relationship between intracellular calcium accumulation and lipid peroxidation.