目的分析金坛市随访人群连续3年宫颈上皮内瘤变(CIN)发病率的变化趋势。方法选择金坛地区自愿接受筛查的18-25岁已婚妇女1458例,采用宫颈液基细胞学检查(TCT)。其结果为不能明确临床意义(ASCUS)者并行高危型HPV-HC2检测,结果阳性者及低度上皮内瘤变(LSIL)以上者均结合阴道镜检查和活检病理诊断。结果 2009年、2010年和2011年宫颈高危病变(HSIL)发病率分别为2.19%、1.60%和0.24%,CIN发病率依次为3.36%、1.89%和0.79%。结论通过每年对高危人群进行宫颈癌及癌前病变的筛查,金坛地区CIN新增发病率有逐年降低趋势。筛查是预防和控制宫颈癌的主要手段。 Objective To analyze the change trend of cervical intraepithelial neoplasia (CIN) incidence in 3 consecutive years in Jintan follow-up population. Methods A total of 1458 married women aged 18-25 years who were screened voluntarily in Jintan area were selected by cervical liquid-based cytology (TCT). The result was a concurrent high-risk HPV-HC2 test that was not clinically significant (ASCUS), and those with positive results and those with low-grade intraepithelial neoplasia (LSIL) were combined with colposcopy and biopsy pathology. Results The incidence rates of HSIL in 2009, 2010 and 2011 were 2.19%, 1.60% and 0.24% respectively. The incidence of CIN was 3.36%, 1.89% and 0.79% respectively. Conclusion The screening of cervical cancer and precancerous lesions in high-risk groups annually decreases the incidence of CIN in Jintan area year by year. Screening is the primary means of preventing and controlling cervical cancer.