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目的了解应用干扰素α(IFNα)治疗儿童慢性乙型肝炎(CHB)发生惊厥的诱因后果及处理方法。方法随访观察了解放军第302医院近10年使用IFNα治疗CHB后发生惊厥的病例,分析其发生的诱因,发作的方式,发作后所产生的不良后果以及对预后和疗效的影响。结果在2659例使用IFNα的CHB患儿中共有60例发生了惊厥,其发生原因多为IFNα所产生的发热的不良反应所导致的热性惊厥。用干扰素不发热者无惊厥发生。发生惊厥后,通过镇静、止惊等处理后恢复较好。没有产生严重不良后果,不影响IFNα的继续使用,亦不影响CHB的预后和疗效。结论 IFNα治疗CHB儿童发生惊厥是可防、可控的。
Objective To investigate the causes and treatment of seizures induced by interferon α (IFNα) in children with chronic hepatitis B (CHB). Methods Follow-up observation of convulsions occurred in the 302nd Hospital of People’s Liberation Army in the past 10 years after treatment of CHB with IFNα was analyzed. The causes of the seizures, the mode of attack, the adverse consequences after the attack and the prognosis and curative effect were analyzed. Results A total of 60 convulsions were found in 2659 CHB patients with IFNα, the most common cause of which was convulsions caused by the adverse effects of IFNα-induced fever. No seizures with interferon fever. After convulsions, by sedating, stopping the shock and other treatment recovery better. Did not produce serious adverse consequences, does not affect the continued use of IFNα, does not affect the prognosis and efficacy of CHB. CONCLUSIONS: IFNα treatment of CHB children with convulsions is preventable and controllable.