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目的 推荐一个乳腺浸润性导管癌的预后指标—癌巢的表面积密度 (Sv)。方法 以Bloom Richardson和Elston分级法 ,对 34 3例乳腺浸润性导管癌进行组织学分级并根据体视学原理 ,采用模板法 ,测定癌实质体积密度(Vv)及癌巢的表面积密度 (Sv)。比较它们与预后的相关性。结果 在与预后有显著相关性的癌组织学分级、癌实质体积密度 (Vv)及癌巢的表面积密度 (Sv)中发现 ,Sv≤ 4 4的患者中 ,89 3%生存 5年以上 ,Sv >5 5的患者中 ,82 5 %死于 5年以内。结论 癌肿生长方式的体视学参数—Sv是可靠且独立的预后指标 ,Vv、组织学分级是乳腺浸润性导管癌预后的相关因素。
Objective To recommend a prognostic marker for breast invasive ductal carcinoma - the surface area density (Sv) of the cancer nests. Methods According to the Bloom Richardson and Elston grading methods, 34 3 breast invasive ductal carcinomas were histologically graded and according to the stereological principle, the Vv and Sv were determined by the template method. . Compare their correlation with prognosis. Results In the histological grade, Vv and Sv of the cancer neoplasms, 89 3% of the patients with Sv≤4 4 survived for more than 5 years and Sv Among 5 5 patients, 82 5% died within 5 years. Conclusions Stereological parameters of cancer growth pattern-Sv is a reliable and independent prognostic factor. Vv and histological grade are the related prognostic factors of breast invasive ductal carcinoma.