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胃粘膜癌前病变(异型增生)可归纳为细胞异型,组织异型和分化异常三大变化。寻找一个能全面反映胃粘膜癌前病变异型度的定量指标,是当今定量研究中急待解决的问题。本文应用自动化图象分析仪(Quantimet 900型,英国产)对131个胃粘膜肠型病灶进行定量分析,以单个腺管内细胞核总面积与细胞面积之比(ING)作为反应细胞核大小、数量及覆层排列程度的客观定量指标,结果发现:单纯性肠化(27个,对照组)为0.165±0.025;轻度异型(30个)为0.210±0.023;中度异型增生(35个为0.229±0.026,重度异型增生(20个)为0.320±0.028;分化型癌(19个)为0.371±0.052。各病变组ING值的频数分布呈正态。各组间的均值有非常显著的差异(P<0.01。因而ING可初步作为反映粘膜癌前病变异型度的
Gastric precancerous lesions (abnormal hyperplasia) can be classified into three major changes: cell abnormality, tissue abnormality and abnormal differentiation. Finding a quantitative index that can fully reflect the variation degree of gastric precancerous lesions is an urgent problem to be solved in today’s quantitative research. In this study, 131 gastric mucosa-intestinal lesions were quantitatively analyzed using an automated image analyzer (Quantimet 900, UK). The ratio of the total area of nucleus to the area of cells (ING) in a single glandular duct was used as the size, number, and coverage of reactive nuclei. The objective quantitative indicators of the extent of stratification showed that: simple intestinal metaplasia (27, control) was 0.165±0.025; mild heteromorphism (30) was 0.210±0.023; moderate dysplasia (35 were 0.229±0.026). Severe dysplasia (20) was 0.320 ± 0.028; differentiated carcinoma (19) was 0.371 ± 0.052. The frequency distribution of ING values in each lesion group was normal. There was a very significant difference between the mean values of each group (P < 0.01. Thus ING can be initially used as a reflection of the variability of precancerous mucosal disease.