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目的:探讨血清免疫球蛋白E(IgE)水平与钙化性主动脉瓣疾病(CAVD)的关系。方法:符合入选标准的394例患者根据超声心动图结果分为CAVD组(n=169)和非CAVD组(non-CAVD组,n=225)。采用化学发光法测定血清IgE水平,分析两组患者间血清IgE水平的差异以及血清IgE水平与CAVD之间的关系。结果:CAVD组患者血清IgE水平显著高于non-CAVD组(113.30 IU/ml vs 63.76 IU/ml,P<0.05),多因素Logistic回归分析也提示两组间血清IgE水平的差异有统计学意义(P<0.05),且血清IgE水平与CAVD显著相关。结论:CAVD组患者血清IgE水平显著增高;血清IgE水平是提示CAVD的独立生化指标,IgE可能在CAVD的发病过程中起重要作用。
Objective: To investigate the relationship between serum immunoglobulin E (IgE) levels and calcific aortic valve disease (CAVD). Methods: 394 eligible patients were divided into CAVD group (n = 169) and non-CAVD group (n = 225) according to echocardiographic results. The level of serum IgE was measured by chemiluminescence. The difference of serum IgE level between two groups of patients and the relationship between serum IgE level and CAVD were analyzed. Results: Serum IgE level in patients with CAVD was significantly higher than that in non-CAVD patients (113.30 IU / ml vs 63.76 IU / ml, P <0.05). Logistic regression analysis also showed that serum IgE levels were significantly different between the two groups (P <0.05), and serum IgE level was significantly correlated with CAVD. CONCLUSION: Serum IgE levels are significantly increased in patients with CAVD. Serum IgE level is an independent biochemical indicator of CAVD. IgE may play an important role in the pathogenesis of CAVD.