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利用~(60)Co照射小鼠,造成再障模型.观察了多抗甲素对照射后小鼠外周血象、CFU-S及CFU-C等的影响.结果证明:小鼠经60Co-γ射线8戈[瑞]全身性一次照射后,第11天给药组平均白细胞总数为5266±4200/mm~3,对照组1922±1757/mm~3(P<0.001);网织红细胞百分率给药组为0.68±0.3%.对照组为0.06± 0.02%(P<0.05);多抗甲素对小鼠脾集落形成的影响,给药组平均脾集落数为9.6±4;对照组为4.3±4,两者有显著性差异(P<0.01).小鼠照射后CFU-C的影响是,给药组CFU-C/培皿为35±37,而对照组为14.24±18/培皿,两组有显著差异(P<0.05).这些结果表明多抗甲素对造血干细胞有保护及促进其生长发育的功能,显示该药对再障确有疗效,其作用为直接影响造血干细胞的功能.本文为临床用药提供了理论根据.
The mice were irradiated with ~ (60) Co, resulting in the model of aplastic anemia. The effects of polyactin on peripheral blood, CFU-S and CFU-C in mice were observed. The results showed that 60Co- The average number of leukocytes in the administration group was 5266 ± 4200 / mm ~ 3 on day 11 and 1922 ± 1757 / mm ~ 3 in the control group (P <0.001) after the whole body irradiation. The reticulocyte percentage Group was 0.68 ± 0.3%, and the control group was 0.06 ± 0.02% (P <0.05). The effect of polyactin A on the spleen colony formation in mice showed that the average number of spleen colonies was 9.6 ± 4 and the control group was 4.3 ± 4, the difference between the two was significant (P <0.01) .The CFU-C in mice after irradiation was 35 ± 37 CFU-C / petri dish in the treatment group and 14.24 ± 18 / petri dish in the control group, The results showed that the effect of poly-A on the protection of hematopoietic stem cells and their growth and development showed that the drug had a definite effect on aplastic anemia and its effect was directly on the function of hematopoietic stem cells This article provides a theoretical basis for clinical medication.