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目的动态血压观察络活喜联合百优解治疗高血压的疗效。方法 110例高血压患者随机分为两组。联合组采用络活喜结合百优解进行治疗,单药组为络活喜治疗,6周一个疗程结束后,监测动态血压的日间均值、夜间均值、24H均值以及血压节律性,疗效,生活质量的改变和生活习惯改善情况进行评价。结果与联合组比较,收缩压的改变情况无论是日间均值、夜间均值以及24H均值方面单药组均较高,差异具有统计学意义(P<0.05);除了夜间均值没有差异外,单药组的其余指标均高于联合组(P<0.05);两组血压节律性与疗效相较,差异均具有统计学意义(P<0.05);联合组舒张压和收缩压的波动均小于单药组,联合组较单药组在躯体、角色、情感、认知、社会功能、整体健康状况评分和汉米尔顿抑郁量表评分改善更明显且具有显著的统计学差异。健康干预后,所有患者的生活习惯改变较干预前改变明显(P<0.05)。结论络活喜联合百优解治疗高血压疗效确切,不仅表现在动态血压监测,在生活质量改善上更大有裨益。
Objective To observe the effect of loxodine and Baiyou solution in treating hypertension by ambulatory blood pressure monitoring. Methods 110 cases of hypertension were randomly divided into two groups. Combination group using Prozac Norvasc combined treatment monotherapy treatment groups as Norvasc, six weeks after a course of treatment, ambulatory blood pressure monitoring mean daytime, nighttime mean, 24H rhythm of blood pressure and mean, efficacy, life Quality changes and improvement of living habits evaluation. Results Compared with combination group, the changes of the mean systolic blood pressure both day and night, and the mean average aspect 24H monotherapy group were higher, the difference was statistically significant (P <0.05); mean no difference except the night, the single drug group were higher than other indicators combined group (P <0.05); blood pressure rhythm and efficacy compared, the differences were statistically significant (P <0.05); combination group diastolic and systolic blood pressure fluctuations are less than monotherapy and combination groups compared to single-agent group in the physical, role, emotional, cognitive, social functioning, overall health and Hamilton depression Rating scale scores improved more obvious and significant statistical difference. After the health intervention, the change of lifestyle of all the patients changed significantly compared with that before the intervention (P <0.05). Conclusion Norvasc joint Prozac treatment of hypertension is effective, not only in ambulatory blood pressure monitoring, there is a greater benefit in terms of quality of life improved.