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目的:分析帕罗西汀联合心理干预脑卒中后抑郁/焦虑的神经功能及康复效果。方法:选择2014年1月-2016年5月接受治疗的50例脑卒中后抑郁/焦虑的患者,按照随机数表法将其分为观察组和对照组,各25例。观察组的患者采用帕罗西汀联合心理干预,对照组采用帕罗西汀治疗,比较两组患者的疗效、HAMD/HAMA评分、SSS评分与BI指数及神经功能缺损评分。结果:观察组患者总有效率(92.00%)明显高于对照组(68.00%),两组患者比较具有统计学意义(P<0.05);经治疗后观察组的HAMD/HAMA评分(9.11±1.36分、11.89±1.45分)低于对照组(8.89±1.35分、9.87±1.37分),观察组患者SSS评分(7.11±1.36分)低于对照组(9.89±1.45),观察组BI指数(9.89±1.45分)高于对照组(80.8±11.37),两组比较差异具有统计学意义(P<0.05);观察组患者治疗后神经功能缺损评分(4.27±1.04分)低于对照组(6.75±1.26),两组比较差异具有统计学意义(P<0.05)。结论:帕罗西汀联合心理干预应用于脑卒中后抑郁/焦虑的患者,能够缓解患者抑郁/焦虑情绪,减少神经功能损伤,提高康复效果,值得在临床推广应用。
OBJECTIVE: To analyze the neurological function and rehabilitation of paroxetine combined with psychological intervention in post-stroke depression / anxiety. Methods: Fifty patients with post-stroke depression / anxiety who were treated from January 2014 to May 2016 were divided into observation group and control group according to the random number table. Patients in the observation group were treated with paroxetine combined with psychological intervention. Patients in the control group were treated with paroxetine. Efficacy, HAMD / HAMA score, SSS score, BI index and neurological deficit score were compared between the two groups. Results: The total effective rate (92.00%) in the observation group was significantly higher than that in the control group (68.00%), and the two groups were statistically significant (P <0.05). The HAMD / HAMA score of the observation group after treatment was 9.11 ± 1.36 (11.89 ± 1.45) in the observation group was lower than that in the control group (8.89 ± 1.35, 9.87 ± 1.37), SSS score (7.11 ± 1.36) in the observation group was lower than that in the control group (9.89 ± 1.45) ± 1.45) was higher than that of the control group (80.8 ± 11.37), the differences between the two groups were statistically significant (P <0.05); the score of neurological deficit (4.27 ± 1.04) in the observation group after treatment was lower than that of the control group (6.75 ± 1.26), the difference between the two groups was statistically significant (P <0.05). Conclusion: The combination of paroxetine and psychological intervention in patients with depression / anxiety after stroke can relieve depression and anxiety, reduce neurological impairment and improve rehabilitation, which is worthy of clinical application.