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血管抑素(angiostatin)最初是从荷瘤小鼠血清及尿液中分离得到的一种蛋白质, 分子量为38 ku. 它与纤溶酶原的一段内部片段一致, 包括纤溶酶原连续5个Kringle结构中的前4个. 体外试验表明, 这种蛋白质具有抑制内皮细胞增殖活性. 在体内, 它能抑制包括小鼠Lewis 肺癌在内的多种肿瘤的生长和转移.
Angiostatin was originally isolated from serum and urine of tumor-bearing mice and has a molecular weight of 38 ku. It is consistent with an internal fragment of plasminogen, including 5 consecutive plasminogens. The first four in the Kringle structure. In vitro experiments showed that this protein has the activity of inhibiting endothelial cell proliferation. In vivo, it can inhibit the growth and metastasis of various tumors including mouse Lewis lung cancer.